Gulping rather than sipping: macropinocytosis as a way of virus entry

► Over 20 different viruses use macropinocytosis as a means to enter host cells. ► Viruses can trigger macropinocytosis using a wide variety of cell surface molecules. ► Macropinocytic signaling varies with the triggering virus. ► Apoptotic mimicry is emerging as a common mechanism used by viruses to trigger macropinocytosis. ► Viruses are becoming valuable tools to study macropinocytosis.