The multifaceted mosquito anti-Plasmodium response

► Mosquito defense against malaria parasites involves an unexpected variety of biological processes. ► Hemolymph immune proteins may form convertase complexes as in the vertebrate complement system. ► Reactive oxygen species and nitric oxide are important determinants of parasite success. ► Mosquito gut flora has both direct and indirect effects promoting Plasmodium killing. ► Designing Biotechnological strategies against Plasmodium transmission.