Enforcing host cell polarity: an apicomplexan parasite strategy towards dissemination

► Intracellular parasites can target host cell motility regulation to enable parasite dissemination. ► To increase host cell motility, parasites manipulate host cell actin dynamics. ► Theileria parasites target host cell actin dynamics and enforce host cell polarization. ► Host cell polarization enables the focal assembly of adhesion and invasion structures that facilitate dissemination.