Evaluation of anti-norovirus IgY from egg yolk of chickens immunized with norovirus P particles

► NoV-specific IgYs were produced by immunizing chickens with P particles. ► The egg yolk antibodies strongly reacted with NoV P particles. ► The IgY blocked NoV VLPs and P particles binding to HBGA receptors. ► Large-scale production of IgY for passive immunization against NoVs is feasible.