کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6136139 1593697 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Survival protein A is essential for virulence in Yersinia pestis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Survival protein A is essential for virulence in Yersinia pestis
چکیده انگلیسی
Plague is a highly pathogenic disease caused by the bacterium Yersinia pestis. There is currently no vaccine available for prophylaxis and antibiotic resistant strains have been isolated, thus there is a need for the development of new countermeasures to treat this disease. Survival protein A (SurA) is a chaperone that has been linked to virulence in several species of bacteria, including the close relative Yersinia pseudotuberculosis. In this study, we aimed to evaluate the role of SurA in virulence of the highly pathogenic Y. pestis by creating an unmarked surA deletion mutant. The Y. pestis ΔsurA mutant was found to be more susceptible to membrane perturbing agents and was completely avirulent in a mouse infection model when delivered up to 2.1 × 105 CFU by the subcutaneous route. This provides strong evidence that SurA would make a promising antimicrobial target.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 92, March 2016, Pages 50-53
نویسندگان
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