Synthesis and synergistic antifungal activities of a pyrazoline based ligand and its copper(II) and nickel(II) complexes with conventional antifungals

► First approach towards the evaluation of Pyrazoline based transition metal complexes as anticandidal agents. ► Complex formation leads to increase in anticandidal activity. ► Drug combination with amphotericin B and fluconazole reversed the order of anticandidal activities. ► A pronounced synergism has been observed in both ligand and the complexes with the conventional antifungals. ► It is exciting to note that the fungicidal potential of normally fungistatic FLC was observed in combination therapy.