Interesting anticandidal effects of anisic aldehydes on growth and proton-pumping-ATPase-targeted activity

► Anisic aldehydes exert their antifungal activity by targeting plasma membrane H+ ATPase activity. ► Inhibition of H+ ATPase leads to intracellular acidification and cell death. ► Position of methoxy group attached to the benzene ring decides antifungal activity of the structure. ► SEM analysis showed severe breakage of the Candida cell. ► Test compounds may thus be taken as an alternate to a novel anticandidal drug.