کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6138687 1594227 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection
چکیده انگلیسی
Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 490, March 2016, Pages 1-5
نویسندگان
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