کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6138787 | 1594225 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of 'HoBi'-like viral populations among persistent infected calves generated under experimental conditions and to inoculum virus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of 'HoBi'-like viral populations among persistent infected calves generated under experimental conditions and to inoculum virus Comparison of 'HoBi'-like viral populations among persistent infected calves generated under experimental conditions and to inoculum virus](/preview/png/6138787.png)
چکیده انگلیسی
Like other members from the Pestivirus genus, 'HoBi'-like pestiviruses cause economic losses for cattle producers due to both acute and persistent infections. The present study analyzed for the first time PI animals derived from a controlled infection with two different 'HoBi'-like strains where the animals were maintained under conditions where superinfection by other pestiviruses could be excluded. The sequence of the region coding for viral glycoproteins E1/E2 of variants within the swarms of viruses present in the PI calves and two viral inoculums used to generate them were compared. Differences in genetic composition of the viral swarms were observed suggesting that host factors can play a role in genetic variations among PIs. Moreover, PIs generated with the same inoculum showed amino acid substitutions in similar sites of the polyprotein, even in serum from PIs with different quasispecies composition, reinforcing that some specific sites in E2 are important for host adaptation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 492, May 2016, Pages 225-231
Journal: Virology - Volume 492, May 2016, Pages 225-231
نویسندگان
M.N. Weber, F.V. Bauermann, D.O. Bayles, C.W. Canal, J.D. Neill, J.F. Ridpath,