کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6138807 | 1594230 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibodies are not required to a protective immune response against dengue virus elicited in a mouse encephalitis model
ترجمه فارسی عنوان
آنتی بادی ها برای پاسخ ایمنی محافظتی علیه ویروس دنج ناشی از یک مدل آنسفالیت موش مورد نیاز نیستند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Generating neutralizing antibodies have been considered a prerequisite to control dengue virus (DENV) infection. However, T lymphocytes have also been shown to be important in a protective immune state. In order to investigate the contribution of both humoral and cellular immune responses in DENV immunity, we used an experimental model in which a non-lethal DENV2 strain (ACS46) is used to intracranially prime Balb/C mice which develop protective immunity against a lethal DENV2 strain (JHA1). Primed mice generated envelope-specific antibodies and CD8+ T cell responses targeting mainly non-structural proteins. Immune sera from protected mice did not confer passive protection to naïve mice challenged with the JHA1 strain. In contrast, depletion of CD4+ and CD8+ T lymphocytes significantly reduced survival of ACS46-primed mice challenged with the JHA1 strain. Collectively, results presented in this study show that a cellular immune response targeting non-structural proteins are a promising way in vaccine development against dengue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 487, January 2016, Pages 41-49
Journal: Virology - Volume 487, January 2016, Pages 41-49
نویسندگان
Jaime Henrique Amorim, Rúbens Prince dos Santos Alves, RaÃza Bizerra, Sara Araújo Pereira, Lennon Ramos Pereira, Denicar Lina Nascimento Fabris, Robert Andreata Santos, Camila Malta Romano, LuÃs Carlos de Souza Ferreira,