کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6138855 1594229 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue
چکیده انگلیسی
In 2010, a new mouse papillomavirus, MmuPV1, was discovered in a colony of NMRI- Foxn1nu/Foxn1nu athymic mice in India. This finding was significant because it was the first papillomavirus to be found in a laboratory mouse. In this paper we report successful infections of both dorsal and ventral surfaces of the rostral tongues of outbred athymic nude mice. We also report the observation that the base of the tongue, the area of the tongue often targeted by cancer-associated high-risk papillomavirus infections in humans, is especially susceptible to infection. A suitable animal model for the study of oral papillomavirus infections, co-infections, and cancers has long been sought. The work presented here suggests that such a model is now at hand.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 488, 15 January 2016, Pages 73-80
نویسندگان
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