کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6139006 | 1594236 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease
ترجمه فارسی عنوان
تلقیح اسپری های ذرات کوچک از گاوی سفید گاوهای برایتون در میمون های ریز باعث بیماری شدید تنفسی می شود
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Cowpox virus (CPXV) inoculation of nonhuman primates (NHPs) has been suggested as an alternate model for smallpox (Kramski et al., 2010, PLoS One, 5, e10412). Previously, we have demonstrated that intrabronchial inoculation of CPXV-Brighton Red (CPXV-BR) into cynomolgus monkeys resulted in a disease that shared many similarities to smallpox; however, severe respiratory tract disease was observed (Smith et al., 2011, J. Gen. Virol.). Here we describe the course of disease after small particle aerosol exposure of rhesus monkeys using computed tomography (CT) to monitor respiratory disease progression. Subjects developed a severe respiratory disease that was uniformly lethal at 5.7 log10 PFU of CPXV-BR. CT indicated changes in lung architecture that correlated with changes in peripheral blood monocytes and peripheral oxygen saturation. While the small particle aerosol inoculation route does not accurately mimic human smallpox, the data suggest that CT can be used as a tool to monitor real-time disease progression for evaluation of animal models for human diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 481, July 2015, Pages 124-135
Journal: Virology - Volume 481, July 2015, Pages 124-135
نویسندگان
Reed F. Johnson, Dima A. Hammoud, Matthew G. Lackemeyer, Srikanth Yellayi, Jeffrey Solomon, Jordan K. Bohannon, Krisztina B. Janosko, Catherine Jett, Kurt Cooper, Joseph E. Blaney, Peter B. Jahrling,