کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139034 1594228 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Suppressing active replication of a live attenuated simian immunodeficiency virus vaccine does not abrogate protection from challenge
ترجمه فارسی عنوان
سرکوب تکرار فعال یک واکسن ویروس نقص ایمنی تخلیه شده زنده، حفاظت از چالش را لغو نمی کند
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Although safety concerns preclude the use of live attenuated HIV vaccines in humans, they provide a useful system for identifying the elusive correlates of protective immunity in the SIV/macaque animal model. However, a number of pieces of evidence suggest that protection may result from prior occupancy of susceptible target cells by the vaccine virus rather than the immune response. To address this, we developed a Nef-deletion variant of an RT-SHIV whose active replication could be shut off by treatment with RT-inhibitors. Groups of macaques were inoculated with the ∆Nef-RT-SHIV and immune responses allowed to develop before antiretroviral treatment and subsequent challenge with wild-type SIVmac239. Vaccinated animals either resisted infection fully or significantly controlled the subsequent viremia. However, there was no difference between animals undergoing replication of the vaccine virus and those without. This strongly suggests that competition for available target cells does not play a role in protection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 489, February 2016, Pages 1-11
نویسندگان
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