کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139443 1594235 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The full-length genome sequences of nine HCV genotype 4 variants representing a new subtype 4s and eight unclassified lineages
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
The full-length genome sequences of nine HCV genotype 4 variants representing a new subtype 4s and eight unclassified lineages
چکیده انگلیسی
We characterized the full-length genomes for nine novel variants of HCV genotype 4 (HCV-4), representing a new subtype 4s and eight unclassified lineages. They were obtained from patients who resided in Canada but all had origins in Africa. An extended maximum clade credibility (MCC) tree was reconstructed after the inclusion of 30 reference sequences. It differentiated 18 assigned subtypes and 10 unclassified lineages within HCV-4. Similar analysis of 102 partial NS5B sequences resulted in another MCC tree that revealed 22 assigned subtypes (4a-4t, 4w, and 4v) and 30 unclassified lineages at the subtype level. Our study shows that HCV-4 is taxonomically complex and it displays high genetic diversity to support an African origin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 482, August 2015, Pages 111-116
نویسندگان
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