کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6139446 | 1594235 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transcriptional response of human umbilical vein endothelial cell to H9N2 influenza virus infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transcriptional response of human umbilical vein endothelial cell to H9N2 influenza virus infection Transcriptional response of human umbilical vein endothelial cell to H9N2 influenza virus infection](/preview/png/6139446.png)
چکیده انگلیسی
Endothelial cells are believed to play an important role in response to virus infection. Here, we used a microarray technology to study the gene expression profile in human umbilical vein endothelial cells at 24Â h postinfection with H9N2 viruses or inactivated H9N2 viral particles. The results showed that H9N2 virus infection induced an abundance of differential expressed genes, exhibiting a transcriptional signature of viral infection. High levels of chemokine gene expressions were detected following treatment. Surprisingly, the most significantly up-regulated genes were mainly interferon-stimulated genes (ISGs), although there was no change in interferon gene expression and interferon protein level. We also found that viral particles were more potent than viruses in inducing ISGs expression. These results suggest that induction of expression of ISGs is mainly dependent on the interaction between viral particles and endothelial cells. Our data offer further insight into the interaction between endothelial cells and H9N2 influenza viruses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 482, August 2015, Pages 117-127
Journal: Virology - Volume 482, August 2015, Pages 117-127
نویسندگان
Wei Wang, Xiang Mu, Lihong Zhao, Jianfang Wang, Yaocheng Chu, Xuejian Feng, Bo Feng, Xiaohong Wang, Jianjun Zhang, Jian Qiao,