کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6139513 | 1594242 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins
ترجمه فارسی عنوان
لنفوویروس های پرتوی به طور متفاوتی توسط پروتئین های ترانس آمیبوئید ناشی از اینترفرون مهار می شوند
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Interferon-induced transmembrane (IFITM) proteins inhibit the entry of a large number of viruses. Not surprisingly, many viruses are refractory to this inhibition. In this study, we report that different strains of HIV and SIV are inhibited by human IFITM proteins to various degrees, with SIV of African green monkeys (SIVAGM) being mostly restricted by human IFITM2. Interestingly, SIVAGM is as much inhibited by human IFITM2 as by IFITM3 of its own host African green monkeys. Our data further demonstrate that the entry of SIVAGM is impaired by human IFITM2 and that this inhibition is overcome by the cholesterol-binding compound amphotericin B that also overcomes IFITM inhibition of influenza A viruses. These results suggest that IFITM proteins exploit similar mechanisms to inhibit the entry of both pH-independent primate lentiviruses and the pH-dependent influenza A viruses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 474, 1 January 2015, Pages 10-18
Journal: Virology - Volume 474, 1 January 2015, Pages 10-18
نویسندگان
Jin Qian, Yann Le Duff, Yimeng Wang, Qinghua Pan, Shilei Ding, Yi-Min Zheng, Shan-Lu Liu, Chen Liang,