کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139643 1594240 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Actin-myosin network is required for proper assembly of influenza virus particles
ترجمه فارسی عنوان
شبکه اکتین-میوزین برای مونتاژ مناسب ذرات ویروس آنفولانزای مورد نیاز است
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- Actin-myosin network is important for the influenza virus production.
- HA forms aggregations at the plasma membrane in the presence of blebbistatin.
- M1 is recruited to the budding site through the actin-myosin network.

Actin filaments are known to play a central role in cellular dynamics. After polymerization of actin, various actin-crosslinking proteins including non-muscle myosin II facilitate the formation of spatially organized actin filament networks. The actin-myosin network is highly expanded beneath plasma membrane. The genome of influenza virus (vRNA) replicates in the cell nucleus. Then, newly synthesized vRNAs are nuclear-exported to the cytoplasm as ribonucleoprotein complexes (vRNPs), followed by transport to the beneath plasma membrane where virus particles assemble. Here, we found that, by inhibiting actin-myosin network formation, the virus titer tends to be reduced and HA viral spike protein is aggregated on the plasma membrane. These results indicate that the actin-myosin network plays an important role in the virus formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 476, February 2015, Pages 141-150
نویسندگان
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