کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139871 1594244 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enterovirus 71 infects brain-derived neural progenitor cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Enterovirus 71 infects brain-derived neural progenitor cells
چکیده انگلیسی
Neural progenitor cells (NPCs) are stem cells that can differentiate into various neural lineage cells. The damage and loss of NPCs are associated with neurological conditions such as cognitive deficits and memory impairment. In a long-term study of patients with EV71, cognitive disorders were observed. Therefore, we hypothesized that NPCs may be permissive to EV71 infection. We demonstrated that NPCs are prone to EV71 infection and that these stem cells can support the active replication of this virus. Furthermore, EV71 infection triggers apoptosis, resulting in significant cell death in infected NPCs. However, EV71 did not replicate in the differentiated cell types that were tested. Our findings suggest that EV71 can infect NPCs and cause the depletion of these cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 468–470, November 2014, Pages 592-600
نویسندگان
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