کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6139987 1594247 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection
چکیده انگلیسی


- Plasma associated ADCC activity is low or absent prior to HIV-1 superinfection.
- ADCC activity correlates with gp120 binding and virus-neutralizing antibody titers.
- HIV superinfected subjects have similar titers of anti-CMV antibodies to controls.

We have previously shown that HIV-1 superinfected Zambian seroconverters mount low binding and neutralizing antibody responses to their primary HIV-1 infecting virus, which could increase susceptibility to re-infection. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC), a process by which virus-infected cells are killed, was also reduced. Superinfected individuals exhibited low ADCC activity compared to non-superinfected individuals, but similar levels of CMV-reactive binding antibodies, suggesting superinfected individuals are capable of generating and maintaining virus-specific antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 462–463, August 2014, Pages 295-298
نویسندگان
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