کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6140218 | 1594250 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Capsid protein: Evidences about the partial protective role of neutralizing antibody-independent immunity against dengue in monkeys
ترجمه فارسی عنوان
پروتئین کپسید: شواهد در مورد نقش محافظتی ضد حساسیت آنتی بادی ضد انسداد در برابر دنگ در میمون
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
The role of cellular immune response in dengue virus infection is not yet fully understood. Only few studies in murine models propose that CD8+ T-cells are associated with protection from infection and disease. At the light of recent reports about the protective role of CD8+ T-cells in humans and the no correlation between neutralizing antibodies and protection observed in several studies, a vaccine based on cell-mediated immunity constitute an attractive approach. Our group has developed a capsid-based vaccine as nucleocpasid-like particles from dengue-2 virus, which induced a protective CD4+ and CD8+ cell-mediated immunity in mice, without the contribution of neutralizing antibodies. Herein we evaluated the immunogenicity and protective efficacy of this molecule in monkeys. Neither IgG antibodies against the whole virus nor neutralizing antibodies were elicited after the antigen inoculation. However, animals developed a cell-mediated immunity, measured by gamma interferon secretion and cytotoxic capacity. Although only one out of three vaccinated animals was fully protected against viral challenge, a viral load reduction was observed in this group compared with the placebo one, suggesting that capsid could be the base on an attractive vaccine against dengue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 456â457, May 2014, Pages 70-76
Journal: Virology - Volumes 456â457, May 2014, Pages 70-76
نویسندگان
Lázaro Gil, Alienys Izquierdo, Laura Lazo, Iris Valdés, Peris Ambala, Lucy Ochola, Ernesto Marcos, Edith Suzarte, Thomas Kariuki, Guadalupe Guzmán, Gerardo Guillén, Lisset Hermida,