کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6140223 | 1594250 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Parvovirus B19 VLP recognizes globoside in supported lipid bilayers
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
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![عکس صفحه اول مقاله: Parvovirus B19 VLP recognizes globoside in supported lipid bilayers Parvovirus B19 VLP recognizes globoside in supported lipid bilayers](/preview/png/6140223.png)
چکیده انگلیسی
Studies have suggested that the glycosphingolipid globoside (Gb4Cer) is a receptor for human parvovirus B19. Virus-like particles bind to Gb4Cer on thin-layer chromatograms, but a direct interaction between the virus and lipid membrane-associated Gb4Cer has been debated. Here, we characterized the binding of parvovirus B19 VP1/VP2 virus-like particles to glycosphingolipids (i) on thin-layer chromatograms (TLCs) and (ii) incorporated into supported lipid bilayers (SLBs) acting as cell-membrane mimics. The binding specificities of parvovirus B19 determined in the two systems were in good agreement; the VLP recognized both Gb4Cer and the Forssman glycosphingolipid on TLCs and in SLBs compatible with the role of Gb4Cer as a receptor for this virus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volumes 456â457, May 2014, Pages 364-369
Journal: Virology - Volumes 456â457, May 2014, Pages 364-369
نویسندگان
Waqas Nasir, Jonas Nilsson, Sigvard Olofsson, Marta Bally, Gustaf E. Rydell,