کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6140502 | 1594256 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17β-estradiol in cervical tissue of FvB and K14E7 transgenic mice. We found that the most dramatic changes in gene expression occurred in K14E7 and FvB groups treated with 17β-estradiol. A large number of differentially expressed genes involved in the immune response were observed in 17β-estradiol treated groups. The E7 oncoprotein mainly affected the expression of genes involved in cellular metabolism. Our microarray data also identified differentially expressed genes that have not previously been reported in cervical cancer. The identification of genes regulated by E7 and 17β-estradiol, provides the basis for further studies on their role in cervical carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 447, Issues 1â2, December 2013, Pages 155-165
Journal: Virology - Volume 447, Issues 1â2, December 2013, Pages 155-165
نویسندگان
Enoc M. Cortés-Malagón, José Bonilla-Delgado, José DÃaz-Chávez, Alfredo Hidalgo-Miranda, Sandra Romero-Cordoba, Aykut Ãren, Haydar Ãelik, Matthew McCormick, José A. MunguÃa-Moreno, Eloisa Ibarra-Sierra, Jaime Escobar-Herrera, Paul F. Lambert,