Human parvovirus B19 infection leads to downregulation of thyroid, estrogen, and retinoid hormone receptor expression

- B19V infection coincides with downregulation of THRα, RXRA, and ERα expression.
- B19V NS1 is sufficient for downregulation of THRα expression.
- B19V NS1 possibly interacts with THRα.
- B19V leads to changes in THRα-related genes PPARG and Cyclin D1 expression.
- B19V leads to changes in expression of other cancer- and cardiac-related genes.

Erythrovirus B19 (B19V) is a member of the family Parvoviridae. Infection with B19V has been linked to a variety of diseases including erythroid, thyroid, neurological and autoimmune diseases. Here we show that infection of primary CD36+ cells with B19V coincides with downregulation of thyroid, retinoid, and estrogen hormone receptors. In addition we show changes in expression of a variety of related downstream signaling genes participating in cancer and cardiac-related diseases in B19V-infected erythroid primary cells.