کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6140987 | 1227190 | 2013 | 7 صفحه PDF | دانلود رایگان |
- We model de novo infection of the same cell with HIV and HTLV.
- We show that co-infection leads to pseudotyping of both viruses with the other Env.
- Replication competent, HIV-Env pseudotyped, HTLV is capable of competing with HIV-1 infection.
HIV-1 and HTLV-1 can infect CD4+ T cells and can co-infect the same individual. In principle, it is possible that both viruses can infect the same CD4+ T cells in dually infected persons. Currently, how efficiently HTLV-1 and HIV-1 co-infects the same cell and the full extent of their biological interactions are not well-understood. Here, we report evidence confirming that both viruses can infect the same cells and that HTLV-1 envelope (Env) can pseudotype HIV-1 viral particles and HIV-1 envelope (Env) can pseudotype HTLV-1 virions to mediate subsequent infections of substrate cells. We also show that the construction of a chimeric HTLV-1 molecular clone carrying the HIV-1 Env in place of its HTLV-1 counterpart results in a replication competent moiety. These findings raise new implications of viral complementation and assortment between HIV-1 and HTLV-1 in dually infected persons.
Journal: Virology - Volume 443, Issue 1, 15 August 2013, Pages 106-112