کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6141510 | 1227257 | 2011 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production](/preview/png/6141510.png)
Cytoplasmic actins have been found interacting with viral proteins and identified in virus particles. We analyzed by confocal microscopy the cytoplasmic β- and γ-actin patterns during the course of Sendai virus infections in polarized cells. We observed a spectacular remodeling of the β-cytoplasmic actin which correlated with productive viral multiplication. Conversely, suppression of M during the course of a productive infection resulted in the decrease of particle production and the absence of β-actin remodeling. As concomitant suppression of β- and γ-actins resulted as well in reduction of virus particle production, we propose that Sendai virus specifically induces actin remodeling in order to promote efficient virion production. Beta- and γ-cytoplasmic actin recruitment could substitute for that of the endosomal sorting complex required for transport (ESCRT) mobilized by other enveloped viruses but apparently not used by Sendai virus.
Journal: Virology - Volume 410, Issue 1, 5 February 2011, Pages 7-16