کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6141825 1227320 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation
چکیده انگلیسی
The measles virus (MV) P gene encodes three proteins: P, an essential polymerase cofactor, and C and V, which have multiple functions including immune evasion. We show here that the MV P protein also contributes to immune evasion, and that tyrosine 110 is required to block nuclear translocation of the signal transducer and activator of transcription factors (STAT) after interferon type I treatment. In particular, MV P inhibits STAT1 phosphorylation. This is shown not only by transient expression but also by reverse genetic analyses based on a new functional infectious cDNA derived from a MV vaccine vial (Moraten strain). Our study also identifies a conserved sequence around P protein tyrosine 110 as a candidate interaction site with a cellular protein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 360, Issue 1, 30 March 2007, Pages 72-83
نویسندگان
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