کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6141961 | 1227358 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TRIM5α-independent anti-human immunodeficiency virus type 1 activity mediated by cyclophilin A in Old World monkey cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cyclophilin A (CypA) is a peptidyl-prolyl isomerase that binds to the capsid protein of human immunodeficiency virus type 1 (HIV-1). TRIM5α is an antiretroviral factor influencing species-specific retroviral replication in Old World monkey (OWM) cells. In the study reported here, we investigated the role of CypA in anti-HIV-1 activity of OWM cells. Exogenous expression of CypA inhibited HIV-1 infection in OWM cells but not in human cells when the function of TRIM5α was suppressed by overexpression of dominant negative form of TRIM5α as well as by using RNA interference. This inhibitory action depended upon the interaction of the CypA moiety with HIV-1 capsid and disruption of CypA and capsid interaction by cyclosporine A enhanced the HIV-1 susceptibility of OWM cells even in the absence of functional TRIM5α. These results point to the presence of novel TRIM5α-independent anti-HIV-1 activity mediated by CypA in OWM cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 375, Issue 2, 5 June 2008, Pages 514-520
Journal: Virology - Volume 375, Issue 2, 5 June 2008, Pages 514-520
نویسندگان
Emi E. Nakayama, Yasuhiro Shingai, Ken Kono, Tatsuo Shioda,