کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6142129 | 1594342 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers](/preview/png/6142129.png)
چکیده انگلیسی
Many pathogens trigger caspase-1-mediated innate immune responses. Avian leukosis virus subgroup J (ALV-J) causes serious immunosuppression and diverse tumors in chicks. The caspase-1 inflammasome mechanism of response to ALV-J invading remains unclear. Here we investigated the expression of caspase-1, the inflammasome adaptor NLRP3, IL-1β and IL-18 in response to ALV-J infection in the liver of chick. We found caspase-1 mRNA expression was elevated at 5 dpi and peaked at 7 dpi in ALV-J infected animals. Corresponding to this, the expressions of NLRP3 and proinflammatory cytokines IL-1β and IL-18 were significantly increased at 5 or 7 dpi. In addition, caspase-1 protein expression and inflammatory cell infiltration were induced after virus infection. These results indicated that ALV-J infection could trigger the caspase-1- mediated inflammatory response in chicks. Thus, an understanding of the inflammatory responses can provide a better insight into the pathogenicity of ALV-J and a possible anti-virus target for ALV-J infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 215, 2 April 2016, Pages 65-71
Journal: Virus Research - Volume 215, 2 April 2016, Pages 65-71
نویسندگان
Xue-lan Liu, Wen-jie Shan, Li-juan Jia, Xu Yang, Jin-jing Zhang, Ya-rong Wu, Fa-zhi Xu, Jin-nian Li,