کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6142295 1594363 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons
ترجمه فارسی عنوان
مجله: سیستم های ژنتیکی معکوس کرونا ویروس: کلون های عفونی و تکثیر
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Coronaviruses (CoVs) infect humans and many animal species, and are associated with respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV genome and the instability of some CoV replicase gene sequences during its propagation in bacteria, represent serious obstacles for the development of reverse genetic systems similar to those used for smaller positive sense RNA viruses. To overcome these limitations, several alternatives to more conventional plasmid-based approaches have been established in the last 13 years. In this report, we briefly review and discuss the different reverse genetic systems developed for CoVs, paying special attention to the severe acute respiratory syndrome CoV (SARS-CoV).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 194, 19 December 2014, Pages 67-75
نویسندگان
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