کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6142659 1228209 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New insights in the role of nucleoporins: A bridge leading to concerted steps from HIV-1 nuclear entry until integration
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
New insights in the role of nucleoporins: A bridge leading to concerted steps from HIV-1 nuclear entry until integration
چکیده انگلیسی
Human Immunodeficiency virus type 1 (HIV-1), as well as many other viruses that depend on nuclear entry for replication, has developed an evolutionary strategy to dock and translocate through the nuclear pore complex (NPC). In particular, the nuclear pore is not a static window but it is a dynamic structure involved in many vital cellular functions, as nuclear import/export, gene regulation, chromatin organization and genome stability. This review aims to shed light on viral mechanisms developed by HIV-1 to usurp cellular machinery to favor viral gene expression and their replication. In particular, it will be reviewed both what is known and what is speculated about the link between HIV translocation through the nuclear pore and the proviral integration in the host chromatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 178, Issue 2, 26 December 2013, Pages 187-196
نویسندگان
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