کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6142962 | 1594379 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunological effects of Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) by stimulation of mice in vivo and in vitro
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunological effects of Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) by stimulation of mice in vivo and in vitro Immunological effects of Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) by stimulation of mice in vivo and in vitro](/preview/png/6142962.png)
چکیده انگلیسی
Baculoviruses are highly specific and only capable of replication in arthropod hosts. The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most studied baculovirus at the molecular level and the Anticarsia gemnatalis multiple nucleopolyhedrovirus (AgMNPV) is the most used viral insecticide worldwide. AcMNPV have also been shown to stimulate the mammalian immune response acting as an adjuvant. In order to evaluate the effects of AgMNPV in modulating macrophage and lymphocyte activation, we have stimulated these cells in vitro and inoculated BALB/c mice intranasally with the two viral phenotypes (PIBs and BVs) and compared with the response induced by the same phenotypes of AcMNPV. Our results showed that baculoviruses are able to modulate mammalian immune response; in vitro they increase phagocytosis, NO2 production and Th1 cells response. In vivo, AgMNPV BVs or PIBs do not induce an inflammatory reaction in normal lung but during a fungal lung infection they can change the type of adaptive response developed. Considering our data, AgMNPV can be considered more useful as a vaccine vector or immune adjuvant than AcMNPV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 176, Issues 1â2, September 2013, Pages 119-127
Journal: Virus Research - Volume 176, Issues 1â2, September 2013, Pages 119-127
نویسندگان
Anamelia Lorenzetti Bocca, Maria Creuza do Espirito Santos Barros, Grace Kelly Menezes Martins, Ana Carolina Oliveira de Araújo, Marcio Jerônimo Souza, Alice Melo Ribeiro, Florêncio Figueiredo, Bergmann Morais Ribeiro,