Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo

► SARS-CoV accessory proteins 6 and 9b interaction is shown for the first time. ► In vivo pull down experiments and proteomic approaches have been used for the identification of the interaction between these SARS-CoV proteins. ► Co-localization of proteins 6 and 9b in SARS-CoV infected cells reinforced this newly described interaction.