Induction of MHC Class I HLA-A2 promoter by dengue virus occurs at the NFκB binding domains of the Class I Regulatory Complex

► Dengue virus upregulate the MHC Class I transcription and mRNA synthesis. ► Class I Regulatory Complex in HLA-A2 promoter contains DV-responsive elements. ► All DV serotypes induce binding of p65/p50 and p65/p65 to κB1 and κB2 elements.