Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes

► fAPN and fDC-SIGN are receptors for FIPV in cell lines. ► The role of these receptors in infection of target cells was studied for both serotypes of FIPV. ► FIPV I infection of monocytes depends on fDC-SIGN. ► Most FIPV I particles already interact with fDC-SIGN at the plasma membrane. ► For FIPV II, both fAPN and fDC-SIGN are involved in infection but only fAPN at the plasma membrane.