کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6143597 | 1228268 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of antiviral treatment and host susceptibility on positive selection in hepatitis C virus (HCV)
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have conducted a large sequence study of the E1-E2 and NS5A regions of the HCV, subtypes 1a and b, both in patients previously treated with interferon, and untreated patients, who later responded, or not, to a combination therapy based on interferon plus ribavirin. We have examined the role played by the number of positively selected sites on disease progression and its relationship with several variables such as patients' age, sex and their risk of acquiring the disease. We have detected three groups of patients that respond or not to combination therapy: responders of intermediate age, older non-responders and young non-responders, they possess an increasing average number of positively selected sites in the E1-E2 region, respectively. We conclude that the host's genetic factors play an important role in whether the disease is contained or becomes chronic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 131, Issue 2, February 2008, Pages 224-232
Journal: Virus Research - Volume 131, Issue 2, February 2008, Pages 224-232
نویسندگان
Nuria Jiménez-Hernández, Vicente Sentandreu, José A. Castro, Manuela Torres-Puente, Alma Bracho, Inmaculada GarcÃa-Robles, Enrique Ortega, Juan del Olmo, Fernando Carnicer, Fernando González-Candelas, Andrés Moya,