کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6148675 1595299 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
چکیده انگلیسی

PurposeWhy early puberty is associated with worse cardiovascular outcomes is unknown. The relationship between puberty and lipids is unclear. Our aim was to assess whether age at puberty was associated with triglyceride and total low-density lipoprotein and high-density lipoprotein cholesterol at age 53 years.MethodsParticipants in a national birth cohort were examined at 15 years, when pubertal stage for boys was assessed and age at menarche reported by the girls' mothers. At 53 years, 3035 were interviewed in their homes by research nurses, where blood was taken.ResultsThere was a significant inverse relationship in women but not men between age at puberty (in years) and triglycerides (regression coefficient −0.2.9, 95% confidence interval −5.5, to −0.04, p = .02), age at puberty, and age at puberty and adult body mass index (BMI; p < .001). Relationships between puberty and lipids were completely explained by BMI or waist circumference at 53 years.ConclusionsIn both sexes earlier maturation was associated with greater BMI and waist circumference in later life, which resulted in greater triglycerides and cholesterol in women. We suggest that intervention after puberty to help avoid obesity in early maturing women may improve their later cardiovascular health.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 20, Issue 9, September 2010, Pages 676-682
نویسندگان
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