ALA-mediated photodynamic effect on apoptosis induction and secretion of macrophage migration inhibitory factor (MIF) and of monocyte chemotactic protein (MCP-1) by colon cancer cells in normoxia and in hypoxia-like conditions in vitro

Detected reduction in MCP-1 secretion appears to be advantage because of tumor's growth limiting but an increase in the secretion of MIF, which is responsible for stimulation of tumor cells proliferation, is an unfavorable effect. These results may be explained by the fact that the used cancer cell lines differ from each other in cancer stage.