Evaluation of a novel high-resolution magnifying videoendoscope that is capable of photodynamic diagnosis and therapy for gastric cancer

- We developed a new magnifying videoendoscope XG-0001 that is capable of PDD and PDT.
- We succeeded in PDD using the XG-0001 and 3 photosensitizers experimentally.
- Two additional cancerous lesions were newly detected by magnifying pharmacoendoscopy.
- 5-ALA PDD and Photofrin PDT for 5 early gastric cancer patients were succeeded.

SummaryObjectiveTo evaluate the usefulness of a novel high-resolution magnifying videoendoscope called the XG-0001 (Fujifilm, Tokyo, Japan) that is capable of PDD and PDT in experimental and clinical situations.Materials and methodsThe fluorescences of three photosensitizers (i.e., porfimer sodium (Photofrin), protoporphyrin IX and talaporfin sodium (Laserphyrin)) were studied experimentally via excitation with a purple diode laser (VDL, wavelength 405 nm). Five consecutive patients with superficial early gastric cancer not indicated for surgery or other curative endoscopic treatment due to complicated serious diseases were enrolled in this study. After close endoscopic examinations, 2 mg/kg of Photofrin were intravenously injected into the patients for PDT, and 5-aminolevulinic acid (ALA; 15-20 mg/kg) was orally taken for PDD. PDD using VDL and PDT using an excimer-dye laser (630 nm, 4 mJ, 60 Hz) were performed with the XG-0001.ResultsPhotofrin and Laserphyrin had experimentally the lowest and highest fluorescence intensities, respectively. The five patients comprised four men and one woman with a mean age 75.2 year and an age range of 56-83 years. Two additional cancerous lesions were newly detected by magnifying pharmacoendoscopy. In each patient, PDD was successfully performed. PDT could also safely performed and CR was obtained in 71.4% (5/7) of the cancerous lesions in five patients, and no serious complications were encountered.ConclusionThe XG-0001, which is based on a simultaneous videoendoscopy method that uses an RGB color chip CCD, proved extremely useful in routine use and also in PDD and PDT for gastric cancer.