کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6155855 | 1597938 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circulating fibrocytes as predictors of adverse events in unstable angina
ترجمه فارسی عنوان
فیبروسیت ها را به عنوان پیش بینی کننده عوارض جانبی در آنژین ناپایدار مورد بررسی قرار می دهد
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کلمات کلیدی
mothers against decapentaplegic homologTIMISMADFACSPCIDDRTGFAUC - AUCunstable angina - آنژین ناپایدارChronic stable angina - آنژین پایدار مزمنsmooth muscle actin - آکنه عضله صافCSA - ایالات مؤتلفهٔ آمریکاcoronary artery disease - بیماری عروق کرونرtransforming growth factor - تبدیل فاکتور رشدThrombolysis In Myocardial Infarction - ترومبولیزیس در انفارکتوس میوکاردCoronary artery bypass surgery - جراحی بای پس عروق کرونرCABG - جراحی کنارگذر سرخرگ تاجیSMA - دبیرستانfluorescence-activated cell sorting - دسته بندی سلول های فعال فلورسنسCAD - طراحی به کمک رایانه یا کَدpercutaneous coronary intervention - مداخله کرونری از راه پوستarea under the curve - منطقه تحت منحنیDiscoidin domain receptor - گیرنده دامنه دیسکوید
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
Half of the patients who present with unstable angina (UA) develop recurrent symptoms over the subsequent year. Identification of patients destined to develop such adverse events would be clinically valuable, but current tools do not allow for this discrimination. Fibrocytes are bone marrow-derived progenitor cells that co-express markers of leukocytes and fibroblasts and are released into the circulation in the context of tissue injury. We hypothesized that, in patients with UA, the number of circulating fibrocytes predicts subsequent adverse events. We enrolled 55 subjects with UA, 18 with chronic stable angina, and 22 controls and correlated their concentration of circulating fibrocytes to clinical events (recurrent angina, myocardial infarction, revascularization, or death) over the subsequent year. Subjects with UA had a >2-fold higher median concentration of both total and activated fibrocytes compared with subjects with chronic stable angina and controls. In UA subjects, the concentration of total fibrocytes identified those who developed recurrent angina requiring revascularization (time-dependent area under the curve 0.85) and was superior to risk stratification using thrombolysis in myocardial infarction risk score and N-terminal pro B-type natriuretic peptide levels (area under the curve, 0.53 and 0.56, respectively, PÂ <Â 0.001). After multivariable adjustment for thrombolysis in myocardial infarction predicted death, MI, or recurrent ischemia, total fibrocyte level was associated with recurrent angina (hazard ratio, 1.016 per 10,000 cells/mL increase; 95% confidence interval, 1.007-1.024; PÂ <Â 0.001). Circulating fibrocytes are elevated in patients with UA and successfully risk stratify them for adverse clinical outcomes. Fibrocytes may represent a novel biomarker of outcome in this population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 172, June 2016, Pages 73-83.e1
Journal: Translational Research - Volume 172, June 2016, Pages 73-83.e1
نویسندگان
Ellen C. Keeley, Robert C. Schutt, Mark A. Marinescu, Marie D. Burdick, Robert M. Strieter, Borna Mehrad,