کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6189915 1601060 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Consortium de détection et prise en charge des atteintes pulmonaires induites par la bléomycine
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Consortium de détection et prise en charge des atteintes pulmonaires induites par la bléomycine
چکیده انگلیسی
Bleomycin is a cytotoxic antibiotic and a component of chemotherapy regimens of germ cell tumors and lymphoma. Bleomycin lung injuries occur in 10% of patients, and lead to severe interstitial pneumonia in 3% of patients. Pulmonary toxicity is related to endothelial cells injury induce by free radicals and inflammatory cytokines. Diagnosis of bleomycin-induced lung toxicity is based on the combination of clinical and radiological features, and requires to rule out differential diagnoses including pneumocystis. “Bleomycin-induced pneumonitis” is the most frequent pattern; eosinophilic pneumonitis and organizing pneumonia are rarer. Occurrence of bleomycin lung toxicity requires an immediate and often permanent discontinuation. Treatment is based on steroid. Regular clinical and pulmonary function tests monitoring are mandatory for early detection of bleomycin-induced lung toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 103, Issues 7–8, July–August 2016, Pages 651-661
نویسندگان
, , , , , , , , , , ,