کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6190005 1257264 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population
چکیده انگلیسی
Single-nucleotide polymorphisms in microRNAs are related to the occurrence, development and prognosis of cancer. The aim of the present study is to investigate the possible influence of the miR-499(rs3746444) polymorphism on the risk of gastric cancer in Chinese population. A total of 363 GC patients and 969 cancer-free controls were enrolled in this study. The genotypes were obtained using MassARRAY method. The results showed that, compared with T allele, C allele was associated with a significantly increased risk of GC (OR = 1.491, 95% CI = 1.155-1.923, P = 0.002). Moreover, a significantly increased risk of GC in subjects with the TC genotype was observed (adjusted OR of 1.559, 95% CI = 1.148-2.117, P = 0.004), compared with the wide type TT. We also found that basically dominant model (TT vs. TC + CC) was suitable for the association between rs6513497 and the risk of GC (OR = 1.568, 95% CI = 1.173-2.097, P = 0.002). However, the same association was also shown in males and females. Meanwhile, rs3746444 was associated with the tumor size of GC patients. The present study indicated that miR-499 rs3746444 might contribute to GC risk and this SNP could be developed as a biomarker for GC prediction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 102, Issue 12, December 2015, Pages 973-978
نویسندگان
, , , , , , , , , , , , , ,