کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6190005 | 1257264 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Single-nucleotide polymorphisms in microRNAs are related to the occurrence, development and prognosis of cancer. The aim of the present study is to investigate the possible influence of the miR-499(rs3746444) polymorphism on the risk of gastric cancer in Chinese population. A total of 363 GC patients and 969 cancer-free controls were enrolled in this study. The genotypes were obtained using MassARRAY method. The results showed that, compared with T allele, C allele was associated with a significantly increased risk of GC (ORÂ =Â 1.491, 95% CIÂ =Â 1.155-1.923, PÂ =Â 0.002). Moreover, a significantly increased risk of GC in subjects with the TC genotype was observed (adjusted OR of 1.559, 95% CIÂ =Â 1.148-2.117, PÂ =Â 0.004), compared with the wide type TT. We also found that basically dominant model (TT vs. TCÂ +Â CC) was suitable for the association between rs6513497 and the risk of GC (ORÂ =Â 1.568, 95% CIÂ =Â 1.173-2.097, PÂ =Â 0.002). However, the same association was also shown in males and females. Meanwhile, rs3746444 was associated with the tumor size of GC patients. The present study indicated that miR-499 rs3746444 might contribute to GC risk and this SNP could be developed as a biomarker for GC prediction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 102, Issue 12, December 2015, Pages 973-978
Journal: Bulletin du Cancer - Volume 102, Issue 12, December 2015, Pages 973-978
نویسندگان
Min Cai, Yitong Zhang, Yanyun Ma, Wenshuai Li, Pei Min, Jigang Qiu, Weihong Xu, Mingqing Zhang, Min Li, Li Li, Yi Liu, Dongqin Yang, Jun Zhang, Fengtao Cheng,