کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6190384 1601116 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tyrosine-kinases inhibitors in recurrent platinum-resistant ovarian cancer patients
ترجمه فارسی عنوان
مهار کننده های تیروزین کیناز در بیماران مبتلا به سرطان تخمدان مقاوم به پلاتین
کلمات کلیدی
سرطان تخمدان، مقاوم در برابر پلاتین، عود، زنان و زایمان، مهارکننده های تیروزین کیناز،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی


- The risk of recurrence in ovarian cancer (OC) represents a common entity.
- The role of tyrosine-kinases inhibitors (TKI) in recurrent OC needs to be clarified.
- This is the largest reported analysis of published data.
- This analysis suggests that TKI could be considered a valid option in recurrent OC.

For many decades, ovarian cancer (OC) has been one of the most common gynecological cancer.Despite advances in OC diagnosis and treatment, the risk of recurrence is ever present and approximately 85% of patients will experience relapse. Recurrent OC after first-line therapy is almost always incurable. Multiple novel therapies, including tyrosine-kinases inhibitors (TKI), have shown promising results, but their role needs to be clarified.In this review we describe the rationale and the clinical evidence regarding the use of TKI for the treatment of recurrent platinum-resistant OC patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 42, January 2016, Pages 41-46
نویسندگان
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