Temporal changes in the efficacy of chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

These data confirm the limited effectiveness of currently available palliative chemotherapy regimens for RMSCCHN patients. Novel therapeutics offering improvements in quality and quantity of life are urgently needed for these patients. Based on these results, the study of such agents as first-line therapy in RMSCCHN patients is entirely justifiable.