کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6190668 1257407 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A contemporary update on rates and management of toxicities of targeted therapies for metastatic renal cell carcinoma
ترجمه فارسی عنوان
به روز رسانی معاصر در میزان و مدیریت سمیت درمان های هدفمند برای کارسینوم سلول های متاستاتیک کلیه
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

BackgroundTo provide an updated review of adverse events associated with sunitinib, pazopanib, bevacizumab, temsirolimus, axitinib, everolimus and sorafenib and their management.Materials and methodsWe performed a PubMed and Cochrane-based review of side effects associated with the seven agents including product monographs to provide an outline of treatment measures aiming to reduce their toxicities. Subject and outcome of interest, design type, sample size, pertinence and quality, and detail of reporting were the indicators of manuscript quality.ResultsAll targeted therapies cause adverse events. Most adverse events may be prevented or tested before they escalate to severe levels.ConclusionPrevention, early recognition, and prompt management of side effects are of key importance and avoid unnecessary dose reductions, which may undermine treatment efficacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 39, Issue 4, June 2013, Pages 388-401
نویسندگان
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