کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6193866 1259167 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Is complete cytoreductive surgery feasible in this patient with ovarian cancer?
ترجمه فارسی عنوان
آیا عمل جراحی سینتیک کامل در این بیمار با سرطان تخمدان قابل انجام است؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی


- Age >60 years, diaphragmatic carcinomatosis and a PCI>10 are independently associated with incomplete cytoreductive surgery.
- A 10-point score is developed based on these three criteria.
- This score may prove useful to identify patients with ovarian cancer in whom complete cytoreductive surgery is feasible.

BackgroundPost-operative residual tumor size is the main prognostic factor in advanced epithelial ovarian cancer. Our objective was to develop a score for predicting the feasibility of complete cytoreductive surgery in patients with advanced epithelial ovarian cancer.Material and methodsUsing data from a retrospective cohort of 123 patients with advanced ovarian cancer, we developed a score for predicting complete cytoreductive surgery, by performing multiple logistic regression after a jackknife procedure.ResultsThree criteria were independently associated with incomplete cytoreductive surgery confirmed by surgery: age >60 years (adjusted odds ratio [aOR], 6.37; 95% confidence interval [95%CI], 1.9-21.3), diaphragmatic carcinomatosis by computed tomography (aOR, 3.34; 95%CI, 1.1-9.9), and a Peritoneal Cancer Index >10 by diagnostic laparoscopy (aOR, 3.8; 95%CI, 1.4-10.2). A 10-point score was developed based on these three criteria. The area-under-the-curve of the score was 0.76 (95%CI, 0.67-0.86). The score discriminated between groups with low and high risks of incomplete cytoreductive surgery (4.4% [95% CI, 0-10.5] and 42.9% [95% CI, 26.3-59.4], respectively). Using a cutoff of 4, sensitivity of the score was 92.8% (95%CI, 83.2-100) and specificity was 77% (95%CI, 67.1-84.9) for predicting incomplete cytoreductive surgery.ConclusionThis easy-to-calculate score may prove useful to identify patients with ovarian peritoneal carcinomatosis in whom complete cytoreductive surgery is feasible.

179

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Oncology - Volume 25, Issue 3, September 2016, Pages 326-331
نویسندگان
, , , , , ,