کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6194487 1259362 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urine microRNAs as potential noninvasive biomarkers in urologic cancers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Urine microRNAs as potential noninvasive biomarkers in urologic cancers
چکیده انگلیسی

Micro-ribonucleic acids (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. The ability of miRNAs to inhibit translation of oncogenes and tumor suppressors implies that they may be involved in carcinogenesis. Our review focuses on the potential of urinary miRNAs to serve as biomarkers of urologic cancers. We discuss in detail the recent knowledge about the origin of urinary miRNAs, their stability, quality control, and their utility as a potential new class of biomarkers in urologic cancer. Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urologic Oncology: Seminars and Original Investigations - Volume 32, Issue 1, January 2014, Pages 41.e1-41.e9
نویسندگان
, , , ,