کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6197617 | 1261193 | 2008 | 6 صفحه PDF | دانلود رایگان |
d-Enantiomer amino acids, endogenously synthesized and degraded in mammals, participate in multiple developmental and physiological processes. We characterize both d-aspartate and its degradative enzyme (d-aspartate oxidase) in post-natal mouse retina. d-Aspartate attains a developmental peak of 886Â nmol/g dry weight at 1-2Â weeks post-natal while l-aspartate transiently declines, consistent with the de novo synthesis of d-aspartate. d-Aspartate is localized in many cell-types in different retinal layers, with a notable shift from outer retina to inner retina with time. d-Aspartate oxidase is localized to horizontal cells by in situ hybridization, immunohistochemistry, and histochemical staining methods. Given that final cell specification, differentiation, and synaptogenesis occur during the immediate 2-week post-natal period in the rodent retina and the dynamic appearance of d-aspartate and d-aspartate oxidase, we propose that d-aspartate plays a role in mammalian retinal development.
Journal: Experimental Eye Research - Volume 86, Issue 4, April 2008, Pages 704-709