Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: An accelerated aging biomarker?

- We compared two groups of patients with bipolar disorder in early and late stages of the disease.
- The early and late groups were characterized following the Staging model suggested by Kapczinski et al., 2009a, 2009b based on time of disease, number of episodes and global functioning.
- Oxidative stress biomarkers did not differ between groups. As well neurotrophic factors.
- The inflammatory biomarkers analyzed also did not differ between groups, except by the chemokine eotaxin/CCL11.
- Suggesting a link between atopy and bipolar disorder. The BD as been a process of neuroprogression.

BackgroundBipolar disorder (BD) is commonly comorbid with many medical disorders including atopy, and appears characterized by progressive social, neurobiological, and functional impairment associated with increasing number of episodes and illness duration. Early and late stages of BD may present different biological features and may therefore require different treatment strategies. Consequently, the aim of this study was to evaluate serum levels of eotaxin/CCL11, eotaxin-2/CCL24, IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFNγ, BDNF, TBARS, carbonyl, and GPx in a sample of euthymic patients with BD at early and late stages compared to controls.MethodsEarly-stage BD patients, 12 late-stage patients, and 25 controls matched for sex and age were selected. 10 mL of peripheral blood was drawn from all subjects by venipuncture. Serum levels of BDNF, TBARS, carbonyl content, glutathione-peroxidase activity (GPx), cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α and IFNγ), and chemokines (eotaxin/CCL11 and eotaxin-2/CCL24) were measured.ResultsThere were no demographic differences between patients and controls. No significant differences were found for any of the biomarkers, except chemokine eotaxin/CCL11, whose serum levels were higher in late-stage patients with BD when compared to controls (p=0.022; Mann-Whitney U test).LimitationsSmall number of subjects and use of medication may have influenced in our results.ConclusionThe present study suggests a link between biomarkers of atopy and eosinophil function and bipolar disorder. These findings are also in line with progressive biological changes partially mediated by inflammatory imbalance, a process referred to as neuroprogression.