کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6240490 1280428 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations
چکیده انگلیسی

BackgroundIn recent years different IRT/PAP protocols have been evaluated, but the individual performance remains unclear. To optimize the IRT/PAP strategy we compared protocols from three regional CF newborn screening centers (Heidelberg, Dresden, and Prague).MethodsWe evaluated the effect of elevating the IRT-cut-off from 50 to 65 μg/l (~ 97.5th to ~ 99.0th percentile), the need of a failsafe protocol (FS, IRT ≥ 99.9th percentile) and the relative performance using either two IRT-dependent PAP-cut-offs or one PAP-cut-off.FindingsElevation of the IRT cut-off to 65 μg/l (~ 99.0th percentile) increased the PPV significantly (Dresden: 0.065 vs. 0.080, p < 0.0001, Prague: 0.052 vs. 0.074, p < 0.0001) without reducing sensitivity. All three IRT/PAP protocols showed a trend towards a higher sensitivity with FS than without and when using one PAP-cut-off instead of two IRT-dependent PAP-cut-offs.ConclusionsFor best performance we suggest an IRT/PAP protocol with an IRT-cut-off close to the 99.0th percentile, FS, and a single PAP-cut-off.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 13, Issue 1, January 2014, Pages 15-23
نویسندگان
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