کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6240584 | 1280430 | 2015 | 7 صفحه PDF | دانلود رایگان |
BackgroundHigh-dose ibuprofen (HDI) is a clinically beneficial anti-inflammatory regimen that may be a useful reagent to study induced sputum inflammatory marker changes over short study periods appropriate for early-phase CF clinical trials.MethodsWe conducted a 28-day, open-label, randomized, controlled trial among 72 clinically stable CF subjects (FEV1 â¥Â 40% predicted) randomized to HDI or routine care that assessed IL-6, IL-8, TNF-α, IL-1-β, free neutrophil elastase, and white cell counts with differentials change from baseline in induced sputum.ResultsIL-6 was the only biomarker with significant within-group change: 0.13 log10 pg/mL mean reduction among ibuprofen-treated subjects (p = 0.04); and no change in the control group. IL-6 change between groups was statistically significant (p = 0.024). No other inflammatory biomarker differences were observed between groups after 28 days.ConclusionAlthough we studied only one agent, HDI, these results suggest that one month may be inadequate to assess anti-inflammatory candidates using markers from induced sputum.
Journal: Journal of Cystic Fibrosis - Volume 14, Issue 6, November 2015, Pages 720-726